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Fonsecaea monophora is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. The aim of this study was to explore the potential mechanism of macrophages against F. monophora, especially the role of melanin during the pathogenic process. We carried out RNA...
The disease burden of chronic‐relapsing and therapy‐refractory superficial dermatophytosis dramatically increased in India within the past 5‐6 years. In order to evaluate the prevalence of this trend, 201 skin scrapings were collected from patients from all parts of India and were tested for dermatophytes using both fungal culture and a PCR‐ELISA directly performed with native skin scrapings. Fungal...
Background
The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU).
Objectives
To develop a standard set of definitions for IFD in critically ill adult patients in ICU.
Methods
Based on a systematic literature review, a list of potential definitions...
Background
The infection rate for dematiaceous fungi has increased rapidly over the most recent decades. However, the treatment for such infections has been lacking in empirical support with oral antifungal agents.
Objectives
To provide a better regimen for dematiaceous infections in future, the Sensititre YeastOne® colorimetric antifungal panels were used and compared with Laboratory Standards...
Background
Vulvovaginal candidiasis (VVC) is a recurrent vaginal condition in childbearing women.
Objectives
The aim of this study was to assess the efficacy of an oral formulation containing Lactobacillus acidophilus GLA‐14, Lactobacillus rhamnosus HN001 and bovine lactoferrin on symptoms and recurrence of VVC as adjuvant therapy to topical clotrimazole.
Patients/Methods
Forty‐eight women positive...
Despite the existence of endemic mycoses in Latin America and the Caribbean, in addition to a large population of patients at risk for invasive mycoses, the capability of medical centres to perform a proper diagnosis in mycology has not been studied in the region. Moreover, availability of antifungal drugs in the region is unknown. Here, we report the results of a survey involving 129 centres in 24...
Background
Limited data exist for epidemiology and outcomes of various agents causing mucormycosis in various clinical settings from developing countries like India.
Objectives
To study the epidemiology and outcomes of various agents causing mucormycosis in different clinical settings in a tertiary care hospital from South India.
Patients and methods
We reviewed details of 184 consecutive patients...
Background
Candida‐associated infections put a significant burden on western healthcare systems. Development of (multi‐)resistant fungi can become untreatable and threaten especially vulnerable target groups, such as the immunocompromised.
Objectives
We assessed antifungal susceptibility and explored possible influence factors of clinical Candida isolates collected from Austrian hospitals between...
Background
The wide pharmacokinetic variability of voriconazole leads to uncertainty regarding adequate exposure.
Objectives
To create a pharmacokinetic model that could help to explain the variability.
Methods
Retrospective review of paediatric patients with cancer. Models were built using Pmetrics.
Results
We analysed 158 trough measurements in 55 patients; in 41.8%, the serum levels were...
Vitamin D has been demonstrated to have an immunomodulatory role in cystic fibrosis with allergic bronchopulmonary aspergillosis (ABPA). Herein, we evaluate supplemental vitamin D in acute‐stage ABPA complicating asthma. Thirty subjects were randomised to receive either prednisolone (n = 15, control) or prednisolone and oral vitamin D (n = 15, intervention arm). Serum vitamin D levels were significantly...
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